WORLD OF REPRODUCTIVE BIOLOGY: Germ Cells Moved by MicroRNAs

Cranes of the World: 5. Comparative Reproductive Biology

Biology of childhood germ cell tumours, focussing on the significance of microRNAs

Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood. Global messenger RNA profiles segregate malignant GCTs primarily by histology, but then also by age, with numerous transcripts showing age-related differential expression. Such differences are likely to account for the heterogeneous clinico-...

Moved by movement

Major depression (MD) is a common and debilitating condition. To expand knowledge on adjunctive treatment perspectives, this thesis explores a physical therapy approach in the treatment of MD. Specifically, in five studies, the thesis aims to: I) examine the quality of evidence for exercise in the treatment of MD; II) explore depression as an embodied phenomenon; III) evaluate the effects of ad...

MicroRNAs in Vascular Biology

Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms. All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orchestrate a series of pathological events. Despite dramatic improvements in the treatment of atherosc...

Porcine reproductive and respiratory syndrome virus replicates in testicular germ cells, alters spermatogenesis, and induces germ cell death by apoptosis.

Like other arteriviruses, porcine reproductive and respiratory syndrome virus (PRRSV) is shed in semen, a feature that is critical for the venereal transmission of this group of viruses. In spite of its epidemiological importance, little is known of the association of PRRSV or other arteriviruses with gonadal tissues. We experimentally infected a group of boars with PRRSV 12068-96, a virulent f...